VIAGRA ERECTION

HIV man’s Viagra bid

March 28, 2007

AN HIV-positive man accused of infecting other men during a seven-year sex spree refused to use protection unless the Department of Human Services provided him with free sexual aids, a court has heard.
Michael John Neal, 48, is facing 121 charges including attempting to infect a person with a very serious disease, intentionally infecting a person and rape.

Melbourne Magistrates’ Court heard DHS health officers visited Mr Neal at his Port Melbourne home in late 2001 following reports from a doctor that he was having unprotected sex with other men.

During the meeting, Mr Neal allegedly admitted to failing to inform sexual partners of his HIV status and exposing them to the disease.

DHS staff visited Mr Neal three more times over the next 18 months and on the fourth visit, Mr Neal demanded DHS pay for Viagra in return for him practising safe sex.

“Mr Neal stated that if DHS was saying he had to use condoms, then the department should pay for the Viagra as he couldn’t maintain an erection while using a condom,” one of the investigating officers said in a report tendered to court.

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Mr Neal later admitted to investigators that when trawling public toilets for sex he would tell prospective partners “are you aware of the implications of unsafe sex”, but would not divulge his status to them.

One of Mr Neal’s former lovers, who cannot be named, told the hearing he believed he was the target of a conversion party — whereby HIV-positive men would be recruited to have sex with him, with the intention of infecting or “breeding” him.

The man said that he became fearful after Mr Neal boasted about “breeding” a 15-year-old boy at his Port Melbourne house.

The court heard Mr Neal and about 15 other men plied the boy with the drug “ice’ before each had unprotected sex with him.

Each time the boy became lucid, he was given more ice, the man said.

Police allege Mr Neal infected two men with HIV and tried to infect a further 14 between 2000 and 2006.

He denies the charges.

The hearing, before Magistrate Peter Reardon, continues on Monday.

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Bayer Schering Pharma Presents Innovations In Men’s Healthcare At The 22nd Annual Meeting Of The European Association Of Urology (EAU)

March 27, 2007

Bayer Schering Pharma AG, Germany, highlighted their expanded new offerings in Men’s Healthcare during a press conference held at the 22nd Annual Meeting of the European Association of Urology (EAU) on March 22, 2007. The event focused on study results from their three products: Levitra®, Testogel® and Nebido®.

The Real-Life Perception of Efficacy, Attitude, Satisfaction and Safety of Levitra® Therapy (REPEAT) study (1) has been designed to help researchers determine why over 50% of couples experiencing sexual problems discontinue treatment. This three year, innovative post marketing surveillance (PMS) study will follow men treated with Levitra® and their female partners in over 20 countries for 12 months. Understanding the couple’s attitude, perception and behaviour during treatment are crucial to good outcomes in PDE-5 therapy such as Levitra®.

Bayer Schering Pharma will use results from REPEAT as a part of their award-winning patient education programmes to help couples continue on treatment. This study is a further example of Bayer Schering’s commitment to ensure that Levitra® helps couples around the world; and follows on from the world-wide release of the very positive results of the Real-Life Safety and Efficacy of Vardenafil (REALISE) study (2). The REALISE study, the largest study of erectile dysfunction (ED) in the world, a PMS study covering 50 countries, 30,000 investigators and over 100,000 patients showed Levitra® to be efficacious and safe when used in the real-world.

“The results obtained from REPEAT will be extremely useful in understanding the interaction between patient, partner and physician when seeking treatment for erectile problems and what can be done to assist men and their partners to achieve optimal results. More importantly, it will help us to establish why some men discontinue treatment even though they continue to suffer from ED. ED can have a huge impact on a relationship and exploring these issues will help healthcare professionals to assist their patients to choose the best treatment” said Hermann Van Ahlen, MD, Professor of Urology, University of Muenster, Germany.

Levitra® is a proven ED treatment to help men and their partners. The COUPLES study (3), also released today at the EAU, compares patient and partner satisfaction with Levitra® as measured by the TSS (Treatment Satisfaction Scale) by exploring pooled results of three multi-centre 12-week randomised, double-blind, placebo-controlled studies of flexible-dose vardenafil versus placebo. Couples agree that Levitra® provided significantly greater satisfaction versus placebo and that satisfaction is achieved by not only to the man, but also to his partner.

The Levitra® CONFIRMED study was undertaken to compare the efficacy and safety of vardenafil (Levitra®) to that of sildenafil (Viagra®) when used on demand in a population of men with ED. The CONFIRMED study demonstrates the non-inferiority of Levitra® in comparison to Viagra® for overall preference and nominal statistical superiority of Levitra® to Viagra® for several frequently used efficacy variables. The results in a total of 1057 men who were randomised to treatment, showed that 38.9% of men expressed an overall preference for Levitra® over Viagra® (34.5%) and 26.6% of patients had no treatment preference. The difference found was not statistically significant. Regarding secondary measures, Levitra® achieved better response for men responding to the Sexual Encounter Profile questions 2 and 3; 83.9% of men taking Levitra® responded positively to SEP2 (p=0.0389) compared with 82.28% for Viagra® and 74.4% of men preferred Levitra® in response to SEP3 (p=0.0038) against 71.6% for Viagra®. 4

The CONFIRMED study avoided biases seen in other comparative trials by consciously creating an unbiased methodology that included 13 separate criteria. Beyond the randomised, double-blind, cross-over design, this trial additionally used equivalent drug doses, randomised the treatment sequence, used a neutral consent form, assessed preference after each treatment period and, importantly, did not eliminate previous non-responders or only include naïve patients.(4)

Levitra® may also be safe and effective in lessening the symptoms of bothersome lower urinary tract age related symptoms such as urgency and frequent urination. An in-vivo study released at the EAU, shows that Levitra® induced significant relaxation of the lower urinary tract tissues, inhibiting the proliferation of human prostate stroma cells and reducing the irritating symptoms of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) (5). The study investigators concluded that Levitra® could be developed to be used as an effective treatment of BPH/LUTS.

For many men, testosterone levels decline naturally as they age. This effect goes unnoticed and is often regarded as a natural phenomenon of aging. However, low testosterone levels can have a serious effect on the quality of life of men and is commonly associated with a decrease in libido, lean body mass and bone density and an increase in visceral fat as well as disturbances in well-being and mood. Eight centres in Austria, Finland, Germany, Ireland, Spain, Sweden and UK recruited 365 patients with decreased testosterone levels and hypogonadal symptoms in this multi-centre, placebo controlled, double-blind, randomised study(6). This study found that treatment with Testogel®, a transdermal 1% hydroalcoholic gel restored testosterone levels in hypogonadal men to normal range. Testogel® treatment had a statistical significant effect on lean body mass versus placebo. Body composition was also favourably influenced by Testogel® treatment compared to placebo.

Nebido®, an intramuscular depot formulation of testosterone undecanoate, can provide safe and effective drug treatment with high satisfaction for men. An open label prospective, one arm study in 16 centres in Germany included 96 hypogonadal patients, with a mean age of 48.6 years. The men received 6 injections of Nebido® over a period of 63 weeks. The results showed that Nebido® not only improved the lipid pattern (reduction of total cholesterol and LDL cholesterol) as well as glycaemia control (levels of blood sugar) but also improved psychological, somatic, and sexual symptoms of testosterone deficiency. There were no clinically relevant side effects and 92.5% of patients assessed treatment with Nebido® as satisfying.(7)

About Erectile Dysfunction

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Erectile dysfunction (ED) is defined as the consistent or recurrent inability of a man to attain and/or maintain a penile erection sufficient for sexual performance.(8) It is estimated that some degree of ED affects about half of all men over the age of 40 and that worldwide an estimated 152 million men suffer from ED.(9) The number of men with ED is expected to more than double to 322 million by 2025.(10) Despite the high prevalence of sexual dysfunction, experts estimate that only 15-20 percent of men with ED are currently treated.(11)

References

1. Real-Life Perception of Efficacy, Attitude, Satisfaction and Safety of Levitra Therapy (REPEAT) Post Marketing Surveillance Study, Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
2. NN, Kathrin Stauch, Herald Landen et al. Real-Life Safety and Efficacy of Vardenafil (REALISE), Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
3. R.C Rosen, W.A Fisher, et al. Couples’ agreement concerning erectile dysfunction is greater with vardenafil than placebo, Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
4. H. Porst, E. Rubio-Aurioles, I. Eardley, et al. Vardenafil versus Sildenafil in men with erectile dysfunction and cardiovascular risk factors: a subgroup analysis, Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
5. P. Sandner, H. Tinel, B. Stelte-Ludwig, et al. Vardenafil Reduces Prostate Hyperplasia and Improves Lower Urinary Tract Symptoms in Rat, Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
6. Pierre-Marc Bouloux for the European Testogel Study Group: Late Onset Hypogonadism in the Aging Male: New Results after 6 Months Treatment with Testosterone Gel (Testogel), Symposium presentation at the 22nd Annual European Association of Urology (EAU), 2007
7. H. M. Behre, J. Elliesen: Safety and efficacy of intramuscular injections of 1000 mg testosterone undecanoate: A prospective multicenter study in hypogonadal men under conditions resembling real-life situations, Abstract Presented at the 22nd Annual European Association of Urology (EAU), 2007
8. A. Jardin, G. Wagner, S. Khory et al. Recommendations of the 1st International Consultation on Erectile Dysfunction. Co-sponsored by the World Health Organisation (WHO), International Consultation on Urological Diseases (ICUD) and Societé Internationale D’Urologie (SIU). p.713
9. R. C Rosen, W. A Fisher, I. Eardley, C. Neiderberger, A. Nada, M. Sand: The Multinational Men’s Attitudes to Life Events and Sexuality (MALES) Study I, Prevalence of Erectile Dysfunction and Related Health Concerns in the General Population. Cur Med Res Op.
10. I. A Aytac, J. B McKinlay, R. J Krane: The likely world increase in erectile dysfunction between 1995 and 2065 and some possible policy consequences. BJU International 1999; 84:50-56 11. J. Southgate: New rivals to Viagra expand the market. Scrip World Pharmaceutical News, 2002

Bayer HealthCare

Bayer HealthCare, a subsidiary of Bayer AG, is one of the world’s leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Diabetes Care and Pharmaceuticals divisions. The pharmaceuticals business operates under the name Bayer Schering Pharma AG. Bayer HealthCare’s aim is to discover and manufacture products that will improve human and animal health worldwide.

Bayer Schering Pharma

Bayer Schering Pharma is a worldwide leading specialty pharmaceutical company. Its research and business activities are focused on the following areas: Diagnostic Imaging, Hematology/Cardiology, Oncology, Primary Care, Specialized Therapeutics and Women’s Healthcare. With innovative products, Bayer Schering Pharma aims for leading positions in specialized markets worldwide. Using new ideas, Bayer Schering Pharma aims to make a contribution to medical progress and strives to improve the quality of life.

Forward-looking statements

This news release contains forward-looking statements based on current assumptions and forecasts made by Bayer Group management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. These factors include those discussed in our public reports filed with the Frankfurt Stock Exchange and with the U.S. Securities and Exchange Commission (including Form 20-F). The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.

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I Think I Love My Wife’: A comic twist to a classic Rohmer

March 15, 2007

For five decades the brilliant French filmmaker Eric Rohmer, now 86, has been writing and directing quiet, pensive, rigorously unemphatic comedies about the baffled relations between men and women.

Because his pictures are (at least superficially) so similar, and because they tend to be action free, it is not always easy to remember which is which. “Le Genou de Claire,” (Claire’s Knee, 1970) is simple enough: It is the one in which a middle-aged man becomes obsessed with the title joint of the title girl. The central event of “Ma Nuit chez Maud” (My Night at Maud’s, 1969) is, of course, that all-night conversation about Pascal between an uptight, earnestly Catholic guy and a sultry woman who is not his fiancée.

“L’Amour l’après-midi” (Chloé in the Afternoon, 1972), the concluding film in Rohmer’s series of “Six Moral Tales,” is a bit wispier in memory. Could it be the one in which the hero takes Viagra and gets so painfully aroused he has to be rushed to the emergency room?

No, that can’t be right. The little blue pill did not exist in 1972, and although Rohmer’s films have dealt with many of the stickier intricacies of sexual attraction, they have never displayed the slightest interest in the wacky complications of a prolonged erection.

The Viagra scene can, however, be found in a new, improbable remake of “L’Amour l’après-midi,” called “I Think I Love My Wife” (opening this week in the United States and in August in Germany). It is directed and co-written by its star, the not notably quiet, pensive or unemphatic Chris Rock.
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The notion of Chris Rock as a Rohmer hero, while maybe a tad counterintuitive, does not seem impossible. And in the spirit of fairness it is probably wise for ticket-holders to leave at the door all traces of art-house attitude, any lingering suspicion that a French-speaking domestic comedy is inherently too precious an object to be entrusted to the rough handling of Americans.

“L’Amour l’après-midi” is a darn good movie, but there is no sense getting reverent about a picture whose lead actress goes by the name Zouzou and whose hero has a closet full of turtlenecks.

Rock and his co-writer, Louis C.K., retain the original’s most radical and least audience-friendly property: “I Think I Love My Wife” is a film about not having sex, about the process by which a man reaches a conscious decision not to satisfy a particular carnal desire. (Rohmer’s women are uniformly hot, so this choice is never arrived at lightly.)

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This is like making an action movie without explosions, a boxing picture with no knockdowns, a cop thriller in which the hero never pulls his gun out of its holster. Rohmer’s trick is to give viewers the sense that under certain circumstances the denial of physical satisfaction can itself be a keen satisfaction of a different kind; he makes his protagonists’ renunciations feel like consummations.

This is not Rock’s trick. Even for a comedian as inventive as he is, it is a challenge to find the funny in the moral theology of renunciation. Actually, he does not try that hard. From the first scenes, in which his character, a suburban husband and father, tells us in voiceover that his wife will not make love with him anymore, it is clear that Rock has decided to translate “renunciation” as “frustration,” because that is something he is fairly sure can get laughs.

“L’Amour l’après-midi” supplies no information on the sexual health of its suburban couple’s marriage, no indication that frequency of conjugal relations is a burning issue for either the hero or his wife. When Rohmer’s suburban père de famille, Frédéric (Bernard Verley), begins to feel tempted by Chloé (Zouzou) — the free-spirited ex of an old friend — you sense that his adulterous impulses have more to do with his ambivalence about respectability that they do with any specific marital grievance, or even with the specific allure of Chloé.

There is a hint of that existential semi-malaise in the intense attraction of Rock’s character, Richard, to his Chloé figure, Nikki (Kerry Washington). But mostly he is really randy.

Does this explicitness about the hero’s motivation violate the spirit of the original? Yes, indeed. The more interesting question, though, is whether transgressions like this are arbitrary or — in a case where the source material is from a very different culture and a very different time — inevitable.

It is an especially vexing issue here because “L’Amour l’après-midi” is a product of the French New Wave, whose highest value was individuality: the profoundly personal expressiveness without which a filmmaker can only be considered — sneeringly — a director, never an auteur

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Men’s health group classifies erectile dysfunction on `rough and ready’ scale

March 13, 2007

A novel method was used by researchers when it came to categorizing the different levels of hardness in men’s penises
By Angelica Oung
STAFF REPORTER
Friday, Mar 09, 2007, Page 2

“Those with mild erectile dysfunction might be having sex almost as often as those without erectile dysfunction. The difference comes in their and their partner’s level of satisfaction.”

Andrew McCullough, urology professor
The Asian Erectile Dysfunction Advisory Council and Training (EDACT) Group’s latest survey may use rather vivid imagery to describe its subjects’ manhood, but one physician said the measurements work.

EDACT conducted a telephone survey of 1,009 Taiwanese men and then classified each man’s manhood in one of four groups — cucumbers, bananas, peeled bananas and conjac jelly.

These groups are supposed to correspond to the erection hardness score (EHS) which goes from one to four, according to Huang Yi-sheng (黃一å‹?), chief physician at Shinkong Hospital’s urology department.

“It’s a rough and ready measure, but it corresponds quite well to more sophisticated indices such as the IIEF or the QEQ,” Huang told a press conference sponsored by Pfizer, the makers of Viagra.at a press conference, yesterday.

IIEF is the International Index of Erectile Function and the QEQ stands for the Quality of Erection Questionnaire. Huang did not mention whether either of those scales also have their vegetable equivalents.

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Seventy-four percent of Taiwanese men fall into the “cucumber” category according to the survey, meaning that they have no erectile dysfunction. Twenty-three percent were designated as “unpeeled bananas,” meaning they suffer mild dysfunction, but are still able to have penetrative sex.

“Peeled bananas,” at 2 percent, and “conjac jellies,” at 1 percent of the population, have moderate and severe erectile dysfunction respectively.

“The old thinking is that if you can maintain penile erection, you do not have erectile dysfunction; the new understanding is related to satisfactory sexual performance” said Andrew McCullough, associate professor of urology at New York University School of Medicine, speaking at the same news conference.

“Those with mild erectile dysfunction might be having sex almost as often as those without erectile dysfunction. The difference comes in their and their partner’s level of satisfaction,” McCullough said. “We used to tell those patients not to worry. But now, with the new generation of erectile dysfunction drugs, it makes no sense not to help them.”

When asked whether those with mild erectile dysfunction might try other measures to improve their sex life before turning to medication, McCullough said “Of course.”

“Exercise, smoking cessation and being more spontaneous with your partner can all be very helpful,” he said. “But ultimately it is very hard to change human behavior.

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Integrative Way: The ED factors

March 8, 2007

A: We realize that this may be a tough issue to approach with your doctor. And we do hope that all men will discuss these types of concerns with their physicians, because they are certainly not alone.

Erectile dysfunction is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. A study in the February issue of the American Journal of Medicine concluded that about 20 percent of all men suffer from ED. When broken down by age, ED affects about 40 percent of men over 40 and about 70 percent of those over 70.

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A number of medical conditions are associated with ED. In an otherwise healthy male, ED may point to the presence of undiagnosed atherosclerosis, or blockage of the arteries. It is linked to conditions such as high blood pressure, diabetes and heart disease. ED also can be a side effect of certain medications, including commonly prescribed antidepressant medications as well as beta blockers for the treatment of high blood pressure.

Lifestyle factors linked to ED include smoking, a sedentary lifestyle and watching excessive TV. Medications such as Viagra are available for the treatment of ED, but of course we advocate lifestyle changes first: Don’t smoke, eat a healthy low-fat diet and get off the couch.

When we take care of ourselves throughout our lifetime, our body usually rewards us with full functionality, even in our older years.

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Viagra craze puts gun in Señor’s pocket

March 6, 2007

A FEW months ago a man walked into a pharmacy in Madrid, pulled out two toy guns and told the attendants to hand over all the Viagra in stock. Two hours later, in what was perhaps a show of gratitude, he returned with two bouquets of roses, before being arrested.

Such are the extremes to which men in a country usually associated with bullfighting and football will go to obtain the male impotency drug nicknamed sexo azul, or blue sex. It costs £53 for a box of eight blue diamond-shaped tablets and has become as popular with teenage clubbers as it is with men in their 70s.
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“There has been a Viagra explosion in Spain,” says Dr Carlos San Martín, who counsels couples and has tried Viagra himself. “Some people are taking it for physiological reasons, but Viagra is also becoming a social phenomenon, a recreational drug that men of all ages are using because they want to be supermen.”

Women are demanding that their boyfriends get prescriptions. Young partygoers are buying tablets from dealers in discos for as much as £41 a pill, cutting them into pieces, and distributing them among their friends, even though doing so diminishes the drug’s effectiveness.

Doctors say some men are even faking symptoms to try to get the tablets, the main ingredient of which, sildenafil citrate, is effective for up to four hours.

Pfizer, the maker of Viagra, says Spain has moved into the vanguard of a European Viagra trend in part because economic prosperity has transformed the country from a relaxed Mediterranean culture, where the siesta was sacrosanct, into an Anglo-Saxon-style, workaholic nation. This new stress, said Belén Alguacil Arconada, a Pfizer spokeswoman, is wreaking havoc with the Spanish male’s libido.

“We used to have a siesta, to sleep all afternoon, to eat well,” she said. “But now we have become a fast-food nation where everyone is stressed out, and this is not good for male sexual performance.”

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Pfizer says it sold nearly one million boxes of Viagra in Spain last year, the equivalent of one box for every 17 men aged 18 and older. Globally, Pfizer earned $1.66bn (£823m) from Viagra sales in 2006.

The quest for Viagra was apparent at a packed disco in Chueca, a bohemian district of Madrid, where a group of young men said they took Viagra because it increased sexual confidence. Santiago, a 32-year-old travel agent, called the drug a “sexual security blanket”.

Medical experts are alarmed by Viagra’s transformation into a party drug, which young men are combining with illegal designer drugs such as Ecstasy to make a cocktail that young clubbers call sextasy.

The increasing sexual assertiveness of Spanish women has also contributed to the Viagra trend. Bárbara Alfonso, who last year opened Spain’s first escort service for women in Barcelona, says Spanish men are struggling to adapt to sexual liberation among women.

She notes, however, that while many men think they need to take Viagra to satisfy women, what women really crave is companionship and good conversation.

“The new generation of women in Spain are less influenced by religion and tradition and are willing to do what it takes to have good sex, whether that means going to an escort service or giving their boyfriends Viagra,” she said.

Not everyone welcomes the country’s Viagra obsession. Nacho Vidal, Spain’s most famous porn star, complains that the widespread use of Viagra is destroying rather than strengthening Spanish male sexuality.

“Everyone is taking Viagra,” he said. “It is the new drug, and this is undermining Spanish men’s credibility. Before, you used to have to perform, but now all you need is a pill.”

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